Pep Guardiola’s side will face opponents down in 13th place in the Bundesliga after losing eight of their first 15 games in that competition.
City director of football Txiki Begiristain warned on the club’s social media: “This competition is getting hard. There are big draws and big games coming.
“Teams that are struggling in their league have done very well in the Champions League. German clubs are always very dangerous.”
However, the Blues are already odds-on favourites to prevail in the opening leg away from home.
There are two other ties between English and German clubs which are rated much harder to call.
Bayern have been inconsistent in the Bundesliga this term, but were unbeaten when topping Group E of this competition with four wins and two draws.
Sporting director Hasan Salihamidzic told the UEFA website: “Liverpool are the hottest team right now and top of the Premier League table.
“They play good football, very physical and with a high tempo. We’re looking forward to playing there. These are the challenges you have to master in your career.”
United drift after daunting draw
Manchester United are out to 50/1 in bwin’s Champions League winner odds after being handed a testing tie against French aristocrats Paris Saint-Germain.
Jose Mourinho’s men must face a formidable forward line featuring Neymar, Kylian Mbappe, Edinson Cavani and former Old Trafford player Angel Di Maria, with PSG rated 8/1 fourth favourites.
Thomas Tuchel’s side scored 17 goals in their Group C campaign to qualify ahead of Liverpool, but were beaten 3-2 at Anfield during September.
Perhaps the tie of the first knockout round will be Atletico Madrid against Juventus, though.
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