With Luis Suarez and Edinson Cavani up front, La Celeste will be seen by many as a value pick to lift the trophy for the third time when assessing the Uruguay World Cup 2018 odds.
Uruguay only made it as far as the last 16 in Brazil four years ago, but they did secure pool-stage victories over England and Italy before being knocked out by Colombia.
At South Africa 2010, they reached the semi-finals, topping their group and beating South Korea and Ghana prior to a 3-2 loss to Holland.
Qualifying for this summer’s tournament went relatively smoothly, with nine wins and four draws in 18 matches helping Uruguay to finish second behind Brazil in the South American section.
Oscar Tabarez’s team will have to prove they can perform away from home, though, as seven of those triumphs came in Montevideo.
Tabarez took charge of the national side at the 1990 World Cup and has now been at the helm for 12 years in his second spell as manager.
The 71-year-old was awarded the FIFA Order of Merit in 2012 for his contribution to the sport and has a Copa America triumph on his CV.
That experience will inspire plenty of positive Uruguay World Cup 2018 betting tips and predictions ahead of an opening clash with Egypt in Ekaterinburg.
Odds correct on date of publication: 21/05/2018
Strike partners Cavani and Suarez provide Uruguay with formidable attacking options.
PSG hitman Cavani topped the scoring charts in South American qualifying with 10, finishing three clear of Lionel Messi, Gabriel Jesus and Alexis Sanchez.
Suarez weighed in with five himself and the former Liverpool forward has had another outstanding season for Barcelona in Spain.
At the other end of the field, inspirational centre-half Diego Godin has amassed well over 115 caps.
The 32-year-old will be buoyed by Atletico Madrid’s Europa League success and a strong showing in LaLiga.
Goalkeeper Fernando Muslera has established himself as a respected shot-stopper with Lazio and Galatasaray and should reach a century of caps this summer.
Uruguay’s midfield may lack star quality, but former Southampton and Middlesbrough recruit Gaston Ramirez did well for Sampdoria in Italy this season.
Rank (world): 17
WC appearances: 12
Best effort: Won in 1930 and 1950
Road to Russia
URU 4-2 Bolivia
Venezuela 0-0 URU
Paraguay 1-2 URU
URU 0-0 Argentina
Peru 2-1 URU
URU 1-4 Brazil
Chile 3-1 URU
URU 2-1 Ecuador
Fernando Muslera (GK)
Diego Godin (D)
Gaston Ramirez (M)
Edinson Cavani (F)
Luis Suarez (F)
Oscar Tabarez – URU