Stadium: Fisht Stadium
TV: BBC One
Sochi could well host the game of the Russia 2018 group stages when Euro 2016 winners Portugal do battle with 2010 world champions Spain.
La Roja must overcome the shock departure of Julen Lopetegui but have history on their side, as they are yet to lose to the Navigators in a World Cup clash, a run of five matches.
That sequence includes beating their Iberian rivals in the quarter-finals in South Africa eight years ago en route to lifting the trophy.
The current well-drilled outfit has been impressive in warm-up matches, so 91/100 for them to prevail again gets the nod in our Portugal vs Spain betting tips.
A Look At Portugal’s Betting Odds
Portugal qualified thanks to a run of nine straight wins, but only secured top spot in their pool after beating nearest challengers Switzerland in the last game to avoid a play-off.
Fernando Santos’ team seem to enjoy the big occasion, but it is worth remembering that they were slow starters in France two years ago.
The Navigators could only manage draws against Iceland, Austria and Hungary during the group stage, before putting together a resilient run of results through the knockout rounds.
With Real Madrid forward Cristiano Ronaldo in their ranks, they are always capable of scoring goals, especially as he will want to make his mark on the country where he plies his trade.
AC Milan striker Andre Silva has emerged as a useful addition to the forward ranks, while much will be expected of Bernardo Silva following a promising first season at Manchester City.
A Look At Spain’s Betting Odds
Spain have bounced back well since crashing out at the group stage in their World Cup defence in Brazil four years ago.
La Roja breezed through qualifying, finishing five points ahead of Italy, and have a great blend of guile and grace in midfield.
Golden oldies such as Andres Iniesta and David Silva are flanked by the fresher legs of Isco, Thiago and Marco Asensio.
Central defenders Sergio Ramos and Gerard Pique can also play a bit, so Spain are well placed to dominate teams in terms of controlling possession.
There is a debate over who should start up front, with Diego Costa, Rodrigo and Iago Aspas bringing different qualities to the party.
However, whichever way they go, their attacking talent is expected to just overpower Ronaldo and Co and 33/4 for a 2-1 triumph completes our Portugal vs Spain betting predictions.
Obviously, Lopetegui’s exit is a concern, but La Roja have enough experienced leaders on the field of play to cope in our opinion.
Group B Standings