Their dream of taking a tenth European crown this season lies in tatters, so it is just as well that Real Madrid’s focus is purely on domestic affairs this weekend.
Aside from playing for second place, local pride is arguably the only thing at stake in the Madrid derby as both Atletico and Real are virtually guaranteed Champions League qualification yet are also all but out of the title running.
Atletico are solid 5/4 favourites to rub salt in Real’s wounds with a victory at the Vicente Calderon, which would move them level on points with Jose Mourinho’s men with five games remaining.
With Atletico losing just once at home in La Liga this season and Real beaten five times on their travels, Los Blancos are 2/1 to win, while the draw is priced at 5/2 in a tough game for the bookies to call.
Much may depend on how Real Madrid pick themselves up from their 4-1 thrashing in Dortmund – and whether they can rally for an unimportant end to the league season when Mourinho looks to be on his way in the summer.
Team selection will be important too as Real must give their all for an unlikely second-leg comeback against Robert Lewandowski and company on Tuesday.
The pressure will probably be on Atletico this weekend though as they seek to end a 14-year winless streak in Madrid derbies.
Despite enjoying a marvellous season, Atletico’s recent home form has not been great, with Diego Simeone’s men taking two wins from their last five fixtures in all competitions at the Vicente Calderon.
If you look beyond their embarrassments in Istanbul and Dortmund, Real’s domestic away form has picked up of late, with four wins and a draw in their last five league and cup away trips.
Given that Real tend to do better domestically when teams take the game to them, I reckon Atletico’s positive play and bitter desire to break their miserable record against Real can play in the visitors’ hands.
Real have taken three 2-1 away wins in the last couple of months, so that could be a scoreline to back at 33/4.
Atletico’s 5-0 win over relegation candidates Granada earlier this month was, interestingly, the first in eight La Liga matches at the Vicente Calderon to see more than two goals.
A narrow Real Madrid win with two goals in total or less can be backed at a huge 13/2, while an away win with three or less combined goals is a 16/5 shout – and that latter selection is where my money will be going.