Holland are undefeated since their 1-0 loss against Spain in the final of the 2010 World Cup and are slight favourites in their clash with Uruguay.
Priced at 3/2 on bwin.com, they find themselves slightly ahead of their opposition, who offer odds of 31/20.
Alternatively, punters may be tempted by the 11/5 odds available on the draw. Using your £25 free bet for joining bwin on this outcome returns £80.
In a rematch of last year’s World Cup semi-final, the Oranje will be hoping to extend their unblemished record, although it could be a tough ask as a number of key players have remained at home.
Bert Van Marwijk will be without Rafael van der Vaart, Wesley Sneijder, Mark van Bommel, Demy de Zeeuw, Theo Janssen, Michel Vorm and Maarten Stekelenburg for the South American trip.
Goalkeeper Tim Krul, who made his debut in the team’s 0-0 draw against Brazil at the weekend, is also likely to start again. The Newcastle man will be hoping to impress as he enjoys a stint between the posts as a result of injuries to Maarten Stekelenburg and Michel Vorm.
As such, Van Marwijk could make some changes from the team that locked horns with Brazil and Jeffrey Bruma, Eljero Elia and Klaas-Jan Huntelaar are all potential starters for Wednesday.
Oscar Tabarez, meanwhile, is unlikely to be presented with the same problems. On the back of a 2-1 friendly loss against Germany last week, the Uruguay coach has no new injury concerns.
Both goalscorers from the sides’ meeting in South Africa are expected to be present in the squad and will no doubt be looking to exact some revenge for that defeat in front of their home crowd.
Punters confident that lightning can strike twice can get odds of 28/1 on a repeat of the World Cup semi final scoreline of 3-2 to the Dutch.
One thing that neither team lacks is the ability to score goals and football betting enthusiasts could be tempted to place a wager on some of the other markets offered by bwin.com.
For example, the 13/20 odds on both teams scoring in the match could attract a lot of the sensible money, while the 11/10 odds on two goals or more being scored in the second half could be viewed as an easy way to make some cash.
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