Second-placed Sweden can take full advantage and move within three points of Group E leaders, the Netherlands with victories in their games in hand against Moldova and Finland.
They will have to do it without influential striker Zlatan Ibrahimovic, however, who has been ruled out of the match with a foot injury and will stay in Sweden to work on his rehabilitation.
The good news for the Blue-Yellow is that Olof Mellberg returns from suspension, while fellow defenders Behrang Safari and Daniel Majstorovic are available after injury.
Goalkeeper Par Hansson is also expected to make his competitive debut.
Despite the changes, Sweden are favourites to win and betting odds of 13/25 can be found on them at bwin.com.
Alternatively, for punters who like to back the underdog, 5/1 is offered on a home win and odds of 57/20 are available on the match ending all square.
Moldova, like their opponents, also face selection problems. They go into the game without influential captain Alexandru Epureanu through injury, while striker Igor Picusciac has been named in the 22-man squad despite fitness concerns.
Lokomotiv Moscow midfielder Stanislav Ivanov is also drafted in following a four-year international absence, along with debutants Vladimir Livsit, Adrian Cascaval and the Moldovan league’s top scorer, Gheorghe Boghiu.
Gavril Balint’s men will be no pushovers, with international football betting fans no doubt noting that they only lost the reverse fixture narrowly in March.
As such, punters could be tempted to back one team to win the game by exactly one goal difference at 8/5.
Betting enthusiasts looking to make the game more exciting could be tempted to place a wager on the number of goals that the game will produce.
Predicting that the clash will be a one-goal affair, for example, is priced at 18/5, two goals sees odds of 13/5 offered, while three goals, as in the sides’ last meeting, can be backed at 13/4.
A winning £10 bet on the game finishing 1-0 to Sweden returns £65. New customers can register here to receive a £25 free bet.