The top two teams in Group I clash in Granada on Friday, with first-placed Spain taking on second-placed Czech Republic.
Given that Spain are the reigning world and European champions and have won their first three games in the group, a home win – priced at 1/4 – looks to be a banker.
However, more attractive returns could be had by betting on Spain to beat their qualification rivals 3-0, as a successful £10 bet on this scoreline at bwin.com would pay £65 at 11/2.
Spain have already racked up ten goals in their qualification campaign to date, hitting three past Scotland, three past Lithuania and four past Liechtenstein.
This is hardly surprising given the fact head coach Vicente del Bosque can call on the attacking talents of Pedro, Fernando Llorente, David Villa and David Silva to name but a few.
Even Fernando Torres, yet to score in a Chelsea shirt, has managed to find the back of the net in Spain’s opening group games – the 27-year-old struck twice in La Furia Roja’s 4-0 win over Liechtenstein – and it wouldn’t be a surprise to see the Iberians continue this rich vein of goalscoring form.
However, if history is anything to go by then the match might be an altogether tighter affair.
Spain and Czech Republic have met twice before – in the qualification campaign for the 1998 World Cup in France.
Just one goal was scored across the two matches, with the first one a 0-0 stalemate in the Czech Republic and the second ending in a 1-0 home win for Spain.
Meanwhile, recent results suggest Spain are not as irresistible as they once were.
They might have got off to a good start to their qualification campaign, but two of their last three friendlies have seen them thumped 4-0 by Portugal and 4-1 by Argentina.
With this in mind, a 0-0 scoreline at half time could be an attractive proposition at 9/4.
A successful £10 bet with bwin on David Villa scoring the first goal would return £25. New customers can register here to receive a £25 free bet.