TNS were seen as strong contenders to progress to the next round before the first leg, but after being held by Cliftonville to a 1-1 draw they are now seen as outsiders.
Football betting fans looking to get in on some competitive action will find Cliftonville are now seen as slight favourites to secure a win this time round, with bwin pricing the Northern Irish side at 5/4 to emerge victorious.
The draw is available at 23/10 and those expecting The New Saints (TNS) to put in an improved performance and get the win to keep their European dreams alive can back the Welsh side to win at 2/1.
Those looking to place multiple football bets this week could also be tempted to back a half-time result, with Cliftonville, who have won their domestic league three times, priced at 9/5 to be in command going into the break.
A deadlock at the 45-minute mark is priced at 23/20, while opting for TNS to be ahead at the break offers odd of 5/2.
Despite being slight outsiders for the match, TNS have proven that they have what it takes to secure victory, having recently beaten their rivals in a friendly match.
That game saw Tommy Breslin’s men run out as 2-1 winners and backing the same score line is priced at 10/1 this time round.
New customers using their free £25 bet to back such a result could walk away with a cool £275 return.
Those who picture the match being a tighter affair could back a repeat of the 1-1 draw for the first leg, which offers odds of 23/4.
However, with Cliftonville at home and favourites to win, the 15/2 odds a 1-0 win for the home side could attract a lot of attention.
And for those not willing to stake a claim on the winner of this tie, bwin also has a number of goal bets available.
Backing a no score game is priced at 8/1, while those expecting the game to produce exactly one goal can find odds of 15/4.
Exactly two, three and four goals can also be backed at 5/2, 16/5 and 5/1 respectively, while those expecting each team to go for the win and produce an attacking display of football can opt for five or more goals during the game at 23/4.
New customers can register here to receive a £25 free bet.